Article
The molecular basis of tRNA selectivity by human pseudouridine synthase 3.
Molecular cell - 11 Jul 2024
Lin Ting-Yu, Kleemann Leon, Jeżowski Jakub, Dobosz Dominika, Rawski Michał, Indyka Paulina, Ważny Grzegorz, Mehta Rahul, Chramiec-Głąbik Andrzej, Koziej Łukasz, Ranff Tristan, Fufezan Christian, Wawro Mateusz, Kochan Jakub, Bereta Joanna, Leidel Sebastian A, Glatt Sebastian
Abstract excerpt
Pseudouridine (Ψ), the isomer of uridine, is ubiquitously found in RNA, including tRNA, rRNA, and mRNA. Human pseudouridine synthase 3 (PUS3) catalyzes pseudouridylation of position 38/39 in tRNAs. However, the molecular mechanisms by which it recognizes its RNA targets and achieves site specificity remain elusive. Here, we determine single-particle cryo-EM structures of PUS3 in its apo form and bound to three...
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