Article
Molecular basis of dihydrouridine formation on tRNA.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011
Yu Futao, Tanaka Yoshikazu, Yamashita Keitaro, Suzuki Takeo, Nakamura Akiyoshi, Hirano Nagisa, Suzuki Tsutomu, Yao Min, Tanaka Isao
Abstract excerpt
Dihydrouridine (D) is a highly conserved modified base found in tRNAs from all domains of life. Dihydrouridine synthase (Dus) catalyzes the D formation of tRNA through reduction of uracil base with flavin mononucleotide (FMN) as a cofactor. Here, we report the crystal structures of Thermus thermophilus Dus (TthDus), which is responsible for D formation at positions 20 and 20a, in complex with tRNA and with a...
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