Article

The new generation hDHODH inhibitor MEDS433 hinders the <i>in vitro</i> replication of SARS-CoV-2

2020-12-07

Abstract excerpt

Identification and development of effective drugs active against SARS-CoV-2 are urgently needed. Here, we report on the anti-SARS-CoV-2 activity of MEDS433, a novel inhibitor of human dihydroorotate dehydrogenase (hDHODH), a key cellular enzyme of the de novo pyrimidines biosynthesis. MEDS433 inhibits in vitro virus replication in the low nanomolar range, and through a mechanism that stems from its ability to bl...

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Literature Corpus work: a0f97b27-a83f-5b82-ab07-e8f73f31f86d
DOI: 10.1101/2020.12.06.412759

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