Article

Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

2024-03-03

Abstract excerpt

Type I Interferons (IFN-I) are central to host protection against viral infections 1 . While any cell can produce IFN-I, Plasmacytoid Dendritic Cells (pDCs) make greater quantities and more varieties of these cytokines than any other cell type 2 . However, following an initial burst of IFN- I, pDCs lose their exceptional IFN-I production capacity and become “exhausted”, a phenotype that associates with enhanced...

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Literature Corpus work: 29ac2285-ca84-507a-9904-e738001fcc53
DOI: 10.1101/2024.02.28.582551

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