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Article

Profound phenotypic deficiencies in mature blood and bone marrow progenitor dendritic cells in chronic lymphocytic leukemia patients.

Leukemia - 1 Aug 2025

Welch Baustin M, Parikh Sameer A, Kay Neil E, Medina Kay L

Abstract excerpt

Chronic lymphocytic leukemia (CLL) patients are immunocompromised and highly vulnerable to serious recurrent infections. Conventional dendritic cells (cDCs) and plasmacytoid DCs (pDCs) are principal sensors of pathogen challenge and are essential in orchestrating innate and adaptive immune responses to resolve infection. This study identified significant deficiencies in six functionally distinct DC subsets in...

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Identifiers

PMID: 40571743
DOI: 10.1038/s41375-025-02579-6
PMCID: PMC12310542

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