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Article

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

Immunity - 1 Oct 2007

Wherry E John, Ha Sang-Jun, Kaech Susan M, Haining W Nicholas, Sarkar Surojit, Kalia Vandana, Subramaniam Shruti, Blattman Joseph N, Barber Daniel L, Ahmed Rafi

Abstract excerpt

Chronic viral infections often result in T cell exhaustion. To determine the molecular signature of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic choriomeningitis virus (LCMV)-specific CD8(+) T cells from chronic infection to functional LCMV-specific effector and memory CD8(+) T cells generated after acute infection. These data showed that exhausted CD8(+) T cells: (1)...

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Identifiers

PMID: 17950003
DOI: 10.1016/j.immuni.2007.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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