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Article

Targeting metabolism to reverse T-cell exhaustion in chronic viral infections.

Immunology - 1 Feb 2021

Sears John D, Waldron Kevin J, Wei Jian, Chang Chih-Hao

Abstract excerpt

CD8 T-cells are an essential component of the adaptive immune response accountable for the clearance of virus-infected cells via cytotoxic effector functions. Maintaining a specific metabolic profile is necessary for these T-cells to sustain their effector functions and clear pathogens. When CD8 T-cells are activated via T-cell receptor recognition of viral antigen, they transition from a naïve to an effector...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32681647
DOI: 10.1111/imm.13238
PMCID: PMC7808153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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