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Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an <i>INSULIN</i> and <i>GLUCAGON</i> double reporter human embryonic stem cell line

2023-04-20

Abstract excerpt

<h4>Summary</h4> Human embryonic stem cell (hESC)-derived pancreatic alpha and beta cells can be used to develop cell replacement therapies to treat diabetes. However, recent published differentiation protocols yield varying amounts of alpha and beta cells amidst heterogeneous cell populations. To visualize and isolate hESC-derived alpha and beta cells, we generated a GLUCAGON-2A- mScarlet and INSULIN-2A-EGFP d...

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Literature Corpus work
29a25784-4ad9-5fc9-90e8-747cbe5e6ec1
DOI
10.1101/2023.04.19.537542
Open publication

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Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an <i>INSULIN</i> and <i>GLUCAGON</i> double reporter human embryonic stem cell lineDOI 10.1101/2023.04.19.537542
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