Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>glucagon</i> is essential for alpha cell transdifferentiation and beta cell neogenesis

7 Apr 2015

Abstract excerpt

The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery of contextual regulators of cell fate acquisition and maintenance. In murine models of diabetes, glucagon-secreting alpha cells transdifferentiate into insulin-secreting beta cells following targeted beta...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Management and Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25852199
DOI: 10.1242/dev.117911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>glucagon</i> is essential for alpha cell transdifferentiation and beta cell neogenesisPMID 25852199Read ↗

Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an <i>INSULIN</i> and <i>GLUCAGON</i> double reporter human embryonic stem cell lineSemantic proximity Read ↗

Growth factor signalling in the regulation of <i>α</i> ‐cell fateSemantic proximity Read ↗

A single-cell atlas of <i>de novo</i> β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafishSemantic proximity Read ↗

Resolving human α <i>versus</i> β cell fate allocation for the generation of stem cell-derived isletsSemantic proximity Read ↗

A δ-cell subpopulation with a pro-β-cell identity confers efficient age-independent recovery in a zebrafish model of diabetesSemantic proximity Read ↗

A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafishSemantic proximity Read ↗

Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell LineSemantic proximity Read ↗

Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent mannersSemantic proximity Read ↗

<i>In vivo</i> studies of glucagon secretion by human islets transplanted in miceSemantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animalsSemantic proximity Read ↗

Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.