Article

<i>In vivo</i> studies of glucagon secretion by human islets transplanted in mice

2019-12-15

Abstract excerpt

Relatively little is known about regulated glucagon secretion by human islet α cells compared to insulin secretion from β cells, despite conclusive evidence of dysfunction in both cell types in diabetes mellitus. Distinct insulin sequences in humans and mice permit in vivo studies of β cell regulation after human islet transplantation in immunocompromised mice, whereas identical glucagon sequences prevent analogo...

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Literature Corpus work: c3d935ab-5fc8-506f-ab25-d718eef4dabd
DOI: 10.1101/2019.12.15.876920

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