Article

Pluripotent stem cell SOX9 and INS reporters facilitate differentiation into insulin-producing cells

2021-02-03

Abstract excerpt

Differentiation of human pluripotent stem cells into insulin-producing stem cell-derived beta cells harbors great potential for research and therapy of diabetes. The SOX9 gene plays a crucial role during development of the pancreas and particularly in the development of insulin-producing cells as SOX9+ cells form the source for NEUROG3+ endocrine progenitor cells. For the purpose of easy monitoring of differentiat...

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Literature Corpus work: 6c4a6df7-8eb3-5662-8d27-97eab75a0c84
DOI: 10.1101/2021.02.02.429390

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