Article

Endocrine-enriched stem cell-derived islets improve long-term safety <i>in vivo</i>

2025-08-23

Abstract excerpt

Fully differentiated stem cell-derived islets (SC-islets) are proven to normalise blood glucose in type 1 diabetic patients. However, the presence of off-target cell types and the immature SC-islet function upon transplantation remain unresolved problems. Here, we established sorting strategies to generate SC-islets with defined glucagon-producing SC-α- and insulin-producing β-cell ratios and assessed their safety...

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Literature Corpus work: 3682e1ad-59e9-5dec-bdce-98cbceaf3257
DOI: 10.1101/2025.08.22.671768

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