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INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

25 Nov 2011

Abstract excerpt

AIMS/HYPOTHESIS: We aimed to generate human embryonic stem cell (hESC) reporter lines that would facilitate the characterisation of insulin-producing (INS⁺) cells derived in vitro. METHODS: Homologous recombination was used to insert sequences encoding green fluorescent protein (GFP) into the INS locus, to create reporter cell lines enabling the prospective isolation of viable INS⁺ cells. RESULTS: Differentiation...

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PMID: 22120512
DOI: 10.1007/s00125-011-2379-y

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