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An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

24 Aug 2024

Abstract excerpt

Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to study diabetes pathologies and develop cell replacement therapies. Although current differentiation protocols yield SCβ cells with varying degrees of maturation, these cells still differ from deceased donor human β cells in several respects. We sought to develop a reporter cell line that could be used to dynamically track SCβ cell...

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Mesenchymal stem cell research
Pancreatic function and diabetes
Pluripotent Stem Cells Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39182839
DOI: 10.1016/j.molmet.2024.102017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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