Article

Generation and long-term expansion of human pancreatic islet organoids <i>in vitro</i>

2026-04-20

Abstract excerpt

The scarcity of expandable, functional human islet cells remains a major barrier to diabetes therapy. Here, we identify PROCR+ cells within adult human islets and establish a defined culture system to generate pancreatic islet organoids. These organoids self-organize into α-, β-, δ-, and PP cells at near-native ratios, exhibit regulated insulin and glucagon secretion, and support exponential in vitro expansion. Si...

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Literature Corpus work: 2f3f7fcc-f5b7-5bdb-a246-42c13132e2d8
DOI: 10.64898/2026.04.15.718643

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