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Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line

19 Nov 2024

Abstract excerpt

Human embryonic stem cell (hESC)-derived pancreatic α- and β-cells can be used to develop cell replacement therapies to treat diabetes. However, recent published differentiation protocols yield varying amounts of α- and β-cells amid heterogeneous cell populations. To visualize and isolate hESC-derived α- and β-cells, we generated a GLUCAGON-2A-mScarlet and INSULIN-2A-EGFP dual fluorescent reporter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39561351
DOI: 10.2337/db24-0756

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