Article

GenomeDISCO: A concordance score for chromosome conformation capture experiments using random walks on contact map graphs

2017-08-29

Abstract excerpt

<h4>Motivation</h4> The three-dimensional organization of chromatin plays a critical role in gene regulation and disease. High-throughput chromosome conformation capture experiments such as Hi-C are used to obtain genome-wide maps of 3D chromatin contacts. However, robust estimation of data quality and systematic comparison of these contact maps is challenging due to the multi-scale, hierarchical structure of chr...

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Literature Corpus work: 2985c763-4391-5d27-b8bb-7fbf3ee82cd9
DOI: 10.1101/181842

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