Article

A <i>Ctnnb1</i> enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

2024-06-24

Abstract excerpt

The β-catenin-dependent canonical Wnt signaling is pivotal in organ development, tissue homeostasis, and cancer. Here we identified an upstream enhancer of Ctnnb1 – the coding gene for β-catenin, named ieCtnnb1 (intestinal e nhancer of Ctnnb1 ), which is crucial for intestinal homeostasis. ieCtnnb1 is predominantly active in the base of small intestinal crypts and throughout the epithelia of large intestine. Kn...

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Identifiers and source

Literature Corpus work: 2976fcad-c0fc-59c0-bf5f-a9f2dcea793f
DOI: 10.1101/2024.06.21.600033

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