Article
Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.
PLoS genetics - 1 Nov 2015
Feng Ying, Sakamoto Naoya, Wu Rong, Liu Jie-Yu, Wiese Alexandra, Green Maranne E, Green Megan, Akyol Aytekin, Roy Badal C, Zhai Yali, Cho Kathleen R, Fearon Eric R
Abstract excerpt
Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated transcription in Wnt pathway signaling. We studied effects of reduced dosage of the Ctnnb1 gene encoding β-catenin in Apc-mutation-induced colon and ovarian mouse...
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