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Article

NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia.

Neoplasia (New York, N.Y.) - 1 Aug 2016

Georgescu Maria-Magdalena, Gagea Mihai, Cote Gilbert

Abstract excerpt

NHERF1/EBP50, an adaptor molecule that interacts with β-catenin, YAP, and PTEN, has been recently implicated in the progression of various human malignancies, including colorectal cancer. We report here that NHERF1 acts as a tumor suppressor in vivo for intestinal adenoma development. NHERF1 is highly expressed at the apical membrane of mucosa intestinal epithelial cells (IECs) and serosa mesothelial cells....

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Source

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Identifiers

PMID: 27566107
DOI: 10.1016/j.neo.2016.07.003
PMCID: PMC5018097

Genes

NHERF1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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