Article

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

2022-06-12

Abstract excerpt

<h4>ABSTRACT</h4> WNT/β-catenin signaling endows cancer cells with proliferative capacity and immune-evasive functions that impair anti-cancer immunosurveillance by conventional, cytoxtoic T cells. However, the impact of dysregulated WNT signalling on unconventional, tissue-resident T cells, specifically in colon cancer is unknown. Here, we show that cancer cells in Apc -mutant mouse models escape immunosurveill...

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Literature Corpus work: 49e98b55-4bd9-5980-8077-99c482ec6627
DOI: 10.1101/2022.06.10.495115

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