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Article

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.

The Journal of cell biology - 3 Feb 2020

Mis Monika, O'Brien Siobhan, Steinhart Zachary, Lin Sichun, Hart Traver, Moffat Jason, Angers Stephane

Abstract excerpt

Activation of Wnt signaling entails βcatenin protein stabilization and translocation to the nucleus to regulate context-specific transcriptional programs. The majority of colorectal cancers (CRCs) initiate following APC mutations, resulting in Wnt ligand-independent stabilization and nuclear accumulation of βcatenin. The mechanisms underlying βcatenin nucleocytoplasmic shuttling remain incompletely defined. Using...

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Identifiers

PMID: 31881079
DOI: 10.1083/jcb.201903017
PMCID: PMC7041691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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