Article

Effect of channel assembly (KCNQ1 or KCNQ1 + KCNE1) on the response of zebrafish I <sub>Ks</sub> to I <sub>Ks</sub> inhibitors and activators

2021-10-27

Abstract excerpt

<h4>ABSTRACT</h4> In cardiac myocytes, the slow component of the delayed rectifier K + current (I Ks ) ensures repolarization of action potential during beta-adrenergic activation or when other repolarizing K + currents fail. As a key factor of cardiac repolarization I Ks should be present in model species used for cardiovascular drug screening, preferably with pharmacological characteristics similar to those...

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Literature Corpus work: f498b9cc-cdb3-5198-8187-53ffd8717560
DOI: 10.1101/2021.10.26.465845

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