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Multimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults.

Biological psychiatry - 15 Jan 2017

Foley Sonya F, Tansey Katherine E, Caseras Xavier, Lancaster Thomas, Bracht Tobias, Parker Greg, Hall Jeremy, Williams Julie, Linden David E J

Abstract excerpt

BACKGROUND: Recent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer's disease (AD). Because neuropathological features of AD can be present several decades before disease onset, we investigated whether effects of polygenic risk are detectable by neuroimaging in young adults. We hypothesized that higher polygenic risk scores...

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Identifiers

PMID: 27157680
DOI: 10.1016/j.biopsych.2016.02.033
PMCID: PMC5177726

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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