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Article

Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 1999

Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn A C, Kirino Y, Greengard P, Suzuki T

Abstract excerpt

Alzheimer's amyloid precursor protein (APP), the precursor of beta-amyloid (Abeta), is an integral membrane protein with a receptor-like structure. We recently demonstrated that the mature APP (mAPP; N- and O-glycosylated form) is phosphorylated at Thr668 (numbering for APP695 isoform), specifically in neurons. Phosphorylation of mAPP appears to occur during, and after, neuronal differentiation. Here we report...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10341243
PMCID: PMC6782598

Genes

APP
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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