Article

Protective Alzheimer’s disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

2022-12-13

Abstract excerpt

<title>Abstract</title><p><bold>Background:</bold>The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection against Alzheimer’s disease (AD). Thereafter, different studies have discovered that the carriers of the APP A673T variant show reduced levels of amyloid beta (Aβ)in the plasma and better cognitive performance at high age.<bold>Methods:</bold>Cer...

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Literature Corpus work: 54bcd6a6-5a34-58d9-be81-828f205b74bb
DOI: 10.21203/rs.3.rs-2275464/v1

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