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High-coverage allele-resolved single-cell DNA methylation profiling by scDEEP-mC reveals cell lineage, X-inactivation state, and replication dynamics

2024-10-03

Abstract excerpt

DNA methylation is a relatively stable epigenetic mark with important roles in development and disease. 1 Since cell-to-cell variation in epigenetic programming can reflect important differences in cell state and fate, it is clear that single-cell methods are essential to understanding this key epigenetic mark in heterogeneous tissues. Existing single-cell whole-genome bisulfite sequencing (scWGBS) methods 2 hav...

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Literature Corpus work: 284e0354-1136-54d1-957a-21d779bd2541
DOI: 10.1101/2024.10.01.616139

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