Article

Atlas-scale Single-cell DNA Methylation Profiling with sciMETv3

2024-08-30

Abstract excerpt

<h4>Summary</h4> Single-cell methods to assess DNA methylation have not yet achieved the same level of cell throughput compared to other modalities. Here, we describe sciMETv3, a combinatorial indexing-based technique that builds on our prior technology, sciMETv2. SciMETv3 achieves nearly a 100-fold improvement in cell throughput by increasing the index space while simultaneously reducing hands-on time and total...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2c03b94-bd1f-592a-9dd5-9b5795dbe158
DOI: 10.1101/2024.08.29.610369

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atlas-scale Single-cell DNA Methylation Profiling with sciMETv3DOI 10.1101/2024.08.29.610369Read

Single-cell DNA methylation analysis tool Amethyst reveals distinct noncanonical methylation patterns in human glial cellsSemantic proximity Read

Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variantsSemantic proximity Read

Massively parallel single-cell profiling of transcriptome and multiple epigenetic proteins in cell fate regulationSemantic proximity Read

A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elementsSemantic proximity Read

scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cellsSemantic proximity Read

Epigenomic complexity of the human brain revealed by single-cell DNA methylomes and 3D genome structuresSemantic proximity Read

Human Body Single-Cell Atlas of 3D Genome Organization and DNA MethylationSemantic proximity Read

SINBAD: a flexible tool for single cell DNA methylation dataSemantic proximity Read

wgbstools: A computational suite for DNA methylation sequencing data representation, visualization, and analysisSemantic proximity Read

High-coverage allele-resolved single-cell DNA methylation profiling by scDEEP-mC reveals cell lineage, X-inactivation state, and replication dynamicsSemantic proximity Read

Integrative Epigenomics: Bioinformatics Strategies for Multi-Omics Data Analysis in Health and DiseaseSemantic proximity Read

A capture methyl-seq protocol with improved efficiency and cost-effectiveness using pre-pooling and enzymatic conversionSemantic proximity Read