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Article

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

Genome research - 1 Sept 2009

Hodges Emily, Smith Andrew D, Kendall Jude, Xuan Zhenyu, Ravi Kandasamy, Rooks Michelle, Zhang Michael Q, Ye Kenny, Bhattacharjee Arindam, Brizuela Leonardo, McCombie W Richard, Wigler Michael, Hannon Gregory J, Hicks James B

Abstract excerpt

DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common feature of cancer genomes. Presently, few methods enable quantitative, large-scale, single-base resolution mapping of DNA methylation states in desired regions of a complex mammalian genome. Here, we present an approach that combines array-based hybrid selection...

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Identifiers

PMID: 19581485
DOI: 10.1101/gr.095190.109
PMCID: PMC2752124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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