Article

Epinephrine inhibits PI3K alpha via the Hippo kinases

2022-07-20

Abstract excerpt

<h4>SUMMARY</h4> The phosphoinositide 3-kinase, p110α, is an essential mediator of insulin signaling and glucose homeostasis. We systematically interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo kinases phosphorylate and completely inhibit its activity. This inhibitory state corresponds to a conformational change of a membrane binding dom...

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Literature Corpus work: 6b525121-63b2-5cc8-b6b2-d0c3f6e37155
DOI: 10.1101/2022.07.19.500601

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