Article

Subcellular distribution of PP1 isoforms in holoenzyme complexes

2022-09-10

Abstract excerpt

Unlike its counterpart Ser/Thr kinases, the predominant Ser/Thr protein phosphatase 1 (PP1) is a promiscuous enzyme that gains its subcellular localization and substrate specificity from a large panel of regulatory proteins with which it associates in predominantly dimeric complexes. Inhibition of specific PP1-mediated dephosphorylation events relies on targeting the regulatory rather than the catalytic subunit, w...

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Literature Corpus work: 2dbba919-8a2d-56a6-bd37-43402a0da50b
DOI: 10.1101/2022.09.09.507380

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