Article

Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic disease

2026-07-03

Abstract excerpt

The human pancreas contains diverse endocrine and exocrine cell populations whose spatial organization is essential for tissue physiology. While single-cell and spatial transcriptomics revealed molecular heterogeneity across pancreatic cell types, linking these states to physiological activity in situ has remained challenging. Here, we combined single-nucleus RNA sequencing, spatial transcriptomics, and functiona...

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Literature Corpus work: e93f7a53-be00-5078-94bf-74e3ce6ca402
DOI: 10.64898/2026.06.30.735261

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