Article

Restoration of <i>PKM1</i> improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism

2024-11-15

Abstract excerpt

Human stem cell-derived β (SC-β) cells still exhibit limited glucose response required for insulin secretion due to glycolytic bottlenecks, yet how these metabolic abnormalities impact glucose response and functional maturation of SC-β cells remains unclear. In this study, we identified a metabolic checkpoint located at PEP accumulation that impeded the functional maturation, which was rescued by restoration of py...

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Literature Corpus work: 2a72ad63-99e9-560e-b474-e9a470a9bdb0
DOI: 10.1101/2024.11.14.623532

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