Article

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids

2024-12-15

Abstract excerpt

The segmentation clock is a molecular oscillator that regulates the timing of somite formation in the developing vertebrate embryo. NOTCH signalling is one of the key pathways required for proper functioning of the segmentation clock. Aberrant NOTCH signalling results in developmental abnormalities such as congenital scoliosis as well as diseases such as T-cell acute lymphoblastic lymphoma (T-ALL). In this study w...

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Literature Corpus work: 28a267b0-ee82-546e-9d34-06ad3b3b6cc2
DOI: 10.1101/2024.12.10.627712

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