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Article

Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.

Development (Cambridge, England) - 1 Jan 2008

Dunty William C, Biris Kristin K, Chalamalasetty Ravindra B, Taketo Makoto M, Lewandoski Mark, Yamaguchi Terry P

Abstract excerpt

Somitogenesis is thought to be controlled by a segmentation clock, which consists of molecular oscillators in the Wnt3a, Fgf8 and Notch pathways. Using conditional alleles of Ctnnb1 (beta-catenin), we show that the canonical Wnt3a/beta-catenin pathway is necessary for molecular oscillations in all three signaling pathways but does not function as an integral component of the oscillator. Small, irregular somites...

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Source

Identifiers

PMID: 18045842
DOI: 10.1242/dev.009266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.PMID 18045842Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

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Disruption of the somitic molecular clock causes abnormal vertebral segmentation.Semantic proximity Read ↗

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