Article
Recapitulating the human segmentation clock with pluripotent stem cells.
Nature - 1 Apr 2020
Matsuda Mitsuhiro, Yamanaka Yoshihiro, Uemura Maya, Osawa Mitsujiro, Saito Megumu K, Nagahashi Ayako, Nishio Megumi, Guo Long, Ikegawa Shiro, Sakurai Satoko, Kihara Shunsuke, Maurissen Thomas L, Nakamura Michiko, Matsumoto Tomoko, Yoshitomi Hiroyuki, Ikeya Makoto, Kawakami Noriaki, Yamamoto Takuya, Woltjen Knut, Ebisuya Miki, Toguchida Junya, Alev Cantas
Abstract excerpt
Pluripotent stem cells are increasingly used to model different aspects of embryogenesis and organ formation1. Despite recent advances in in vitro induction of major mesodermal lineages and cell types2,3, experimental model systems that can recapitulate more complex features of human mesoderm development and patterning are largely missing. Here we used induced pluripotent stem cells for the stepwise in vitro...
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