Article
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.
Nature communications - 13 Feb 2017
Almine Jessica F, O'Hare Craig A J, Dunphy Gillian, Haga Ismar R, Naik Rangeetha J, Atrih Abdelmadjid, Connolly Dympna J, Taylor Jordan, Kelsall Ian R, Bowie Andrew G, Beard Philippa M, Unterholzner Leonie
Abstract excerpt
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA receptors have been described, but whether their functions are redundant, tissue-specific or integrated in the cGAS-cGAMP pathway is unclear. Here we show that interferon-γ inducible protein 16...
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