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Article

DNA Sensing in the Innate Immune Response

6 Feb 2020

Abstract excerpt

The innate immune system recognizes conserved pathogen-associated molecular patterns and produces inflammatory cytokines that direct downstream immune responses. The inappropriate localization of DNA within the cell cytosol or endosomal compartments indicates that a cell may either be infected by a DNA virus or bacterium, or has problems with its own nuclear integrity. This DNA is sensed by certain receptors that...

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Identifiers

PMID: 32027562
DOI: 10.1152/physiol.00022.2019

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