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Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

21 Jul 2015

Abstract excerpt

Infection of cells with DNA viruses triggers innate immune responses mediated by DNA sensors. cGMP-AMP synthase (cGAS) is a key DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which binds to and activates stimulator of interferon genes (STING), leading to IFN production and an antiviral response. Kaposi's sarcoma-associated herpesvirus (KSHV) is a DNA virus that is linked to...

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PMID: 26199418
DOI: 10.1073/pnas.1503831112

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