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Article

Human DNA-PK activates a STING-independent DNA sensing pathway

3 Jan 2020

Abstract excerpt

Detection of intracellular DNA by the cGAS-STING pathway activates a type I interferon-mediated innate immune response that protects from virus infection. Whether there are additional DNA sensing pathways, and how such pathways might function, remains controversial. We show here that humans-but not laboratory mice-have a second, potent, STING-independent DNA sensing pathway (SIDSP). We identify human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31980485
DOI: 10.1126/sciimmunol.aba4219

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