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Restricted MHC-II trafficking in <i>Mycobacterium tuberculosis</i> -infected M2-like macrophages limits CD4+ T cell activation

2026-07-10

Abstract excerpt

Recognition of infected macrophages by CD4+ T cells is essential to immune protection against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). However, not all infected macrophage subsets successfully elicit T cell activation. We recently discovered that M2-like macrophages fail to efficiently activate memory CD4+ T cells when infected with Mtb, yet successfully elicit T cell activation...

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Literature Corpus work
286d5ff9-5382-5ab3-ac47-3282829241c8
DOI
10.64898/2026.07.07.736943
Open publication

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