Article

Lineage 2–Beijing <i>Mycobacterium tuberculosis</i> strains suppress BCG-trained innate immunity early after infection

2026-04-01

Abstract excerpt

<h4>Summary</h4> Genetically distinct lineages of Mycobacterium tuberculosis differ in their virulence, transmissibility, and immune evasion capacity. The modern Lineage 2-Beijing (L2-B) clade of Mtb , which is highly prevalent in Asia and now globally distributed, is associated with resistance to the bacille Calmette Guérin (BCG) vaccine. Using a murine BCG vaccination model followed by aerosol challenge with...

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Literature Corpus work: 902e2c31-dc43-5373-a8f9-013792892d06
DOI: 10.64898/2026.03.29.714649

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