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Human memory CD4 <sup>+</sup> T-cells recognize <i>Mycobacterium tuberculosis</i> -infected macrophages amid broader pathogen-specific responses

2025-02-27

Abstract excerpt

<h4>Summary</h4> Recognition of macrophages infected with Mycobacterium tuberculosis (Mtb) is essential for CD4 + T cells to prevent tuberculosis (TB). Yet not all antigen-specific T cells recognize infected macrophages in human and murine models. Using monocyte-derived macrophages (MDMs) and autologous memory CD4 + T cells from individuals with latent Mtb infection (LTBI), we quantify T cell activation in res...

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Literature Corpus work
12be8863-d379-5db5-8a13-9a94e00ce25b
DOI
10.1101/2025.02.23.639515
Open publication

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Human memory CD4 <sup>+</sup> T-cells recognize <i>Mycobacterium tuberculosis</i> -infected macrophages amid broader pathogen-specific responsesDOI 10.1101/2025.02.23.639515
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