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Single-cell immune profiling at time of <i>M. tuberculosis</i> exposure reveals antigen-reactive programs that predict progression to active disease

2025-04-30

Abstract excerpt

Early delineation of host immune responses at the moment of Mycobacterium tuberculosis (Mtb) exposure and infection is critical to identify individuals at risk of progressing to active tuberculosis (TB). We performed single-cell transcriptional profiling of over 500,000 peripheral blood mononuclear cells from 57 HIV-negative close contacts of TB cases in Brazil, including 25 individuals who developed active disea...

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Literature Corpus work
6c6a6119-38bc-586b-80ca-b7b6f4a5c259
DOI
10.1101/2025.04.29.25326433
Open publication

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Single-cell immune profiling at time of <i>M. tuberculosis</i> exposure reveals antigen-reactive programs that predict progression to active diseaseDOI 10.1101/2025.04.29.25326433
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