Article

Trans-ancestry polygenic models for the prediction of LDL blood levels: An analysis of the UK Biobank and Taiwan Biobank

2023-08-06

Abstract excerpt

<h4>Background</h4> Polygenic risk scores (PRSs) are proposed for use in clinical and research settings for risk stratification. PRS predictions often show bias toward the population of available genome-wide association studies, which is typically of European ancestry. This study aims to assess the performance differences of ancestry-specific PRS and test the implementation of multi-ancestry PRS to enhance the gen...

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Literature Corpus work: 284a3e3e-0e70-5dcc-9157-7e27770c9df7
DOI: 10.1101/2023.08.03.23293320

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