Article
Population-specific polygenic risk scores for people of Han Chinese ancestry.
Nature - 1 Dec 2025
Chen Hung-Hsin, Chen Chien-Hsiun, Hou Ming-Chih, Fu Yun-Ching, Li Ling-Hui, Chou Che-Yu, Yeh Erh-Chan, Tsai Ming-Fang, Chen Chun-Houh, Yang Hsin-Chou, Huang Yen-Tsung, Liu Yi-Min, Wei Chun-Yu, Su Jen-Ping, Lin Wan-Jia, Wang Elin H F, Chiang Chi-Lu, Jiang Jeng-Kai, Lee I-Hui, Liang Kung-Hao, Chen Wei-Sheng, Tsai Hung-Cheng, Lin Shih-Yao, Chang Fu-Pang, Ho Hsiang-Ling, Yeh Yi-Chen, Tseng Wei-Cheng, Lin Ming-Hwai, Chang Hsiao-Ting, Tseng Ling-Ming, Liang Wen-Yih, Chen Paul Chih-Hsueh, Hsieh Yu-Cheng, Chen Yi-Ming, Hsiao Tzu-Hung, Lin Ching-Heng, Chen Yen-Ju, Chen I-Chieh, Mao Chien-Lin, Chang Shu-Jung, Chang Yen-Lin, Liao Yi-Ju, Lai Chih-Hung, Lee Wei-Ju, Tung Hsin, Yen Ting-Ting, Yen Hsin-Chien, Chen Ming-Yao, Lin Ying-Chin, Kao Yung-Ta, Kao Bi-Zhen, Lee Jing-Er, Chung Chi-Li, Liu Ju-Chi, Chan Paul, Lin Chang-Hsien, Chen Chia-Hsin, Wu I-Chen, Lin Lung-Chang, Wang Jiunn-Wei, Shih Shen-Liang, Hsieh Sun-Wung, Hung Chih-Hsing, Li Wei-Ming, Yang Chih-Jen, Yang Cheng-Shin, Weng Ru-Hui, Chen Yu-Chi, Chang Chun-Ping, Wu Tai-Hsun, Lin Yu-Chang, Sheen Yi-Jing, Wang Shi-Heng, Chen Sye-Pu, Raben Timothy, Widen Erik, Hsu Stephen, Hsieh Feng-Jen, Ho Dong-Ru, Huang Yu-Huei, Yang Chung-Han, Huang Yu-Shu, Chen Yen-Fu, Wu Hsien-Ming, Tsai Ping-Han, Huang Kuan-Gen, Chien Chih-Yen, Ho Yi-Lwun, Wu Ming-Shiang, Kao Jia-Horng, Liu Yen-Bin, Juang Jyh-Ming Jimmy, Lin Mao-Hsin, Lin Yen-Hung, Lee Ji-Yuh, Lu Hsueh-Ju, Lu Chieh-Hua, Feng An-Chieh, Liu Jhih-Syuan, Chiang Chien-Ping, Chu Nain-Feng, Lin Jung-Chun, Yeh Yi-Wei, Meng En, Huang Chih-Yang, Li Chi-Cheng, Wang Tso-Fu, Su Kuei-Ying, Wang Jia-Kang, Chen Mei-Hsiu, Chen Hua-Fen, Ma Gwo-Chin, Chang Ting-Yu, Chiang Fu-Tien, Chang Hsing-Jung, Kao Kuo-Jang, Hung Chen-Fang, Tsai Ching-Yao, Chen Po-Yueh, Tsui Kochung, Chen Yuan-Tsong, Kwok Pui-Yan, Sheu Wayne Huey-Herng, Yang Shun-Fa, Liou Jyh-Ming, Wang Jaw-Yuan, Chiou Jeng-Fong, Wu Jer-Yuarn, Fann Cathy S J
Abstract excerpt
Predicting complex disease risks on the basis of individual genomic profiles is an advancing field in human genetics1,2. However, most genetic studies have focused on populations of European ancestry, creating a global imbalance in precision medicine and underscoring the need for genomic research in non-European groups3,4. The Taiwan Precision Medicine Initiative recruited more than half a million Taiwanese...