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Article

Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries.

NEJM evidence - 1 Nov 2025

Urbut Sarah M, Chen Qiuli, Sui Yang, Misra Anika, Koyama Satoshi, Hornsby Whitney, Peloso Gina M, Finer Sarah, van Heel David A, Ito Kaoro, Alkuraya Fowzan, Fahed Akl C, Wang Minxian, Natarajan Pradeep

Abstract excerpt

BACKGROUND: Clinical trials of low-density lipoprotein cholesterol (LDL-C)-lowering medicines have shown improvement in cardiovascular disease risk. However, representation across diverse communities in such trials is limited. We set out to study whether or not more diverse human genetic studies could provide an opportunity to test whether these trial results can be generalized to poorly populations poorly...

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Identifiers

PMID: 41147828
DOI: 10.1056/EVIDoa2500105
PMCID: PMC13403192

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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