The genetic evolution of acral melanoma

Abstract excerpt

Acral melanoma is an aggressive type of melanoma with unknown origins, arising on the sole, palm, or nail apparatus. It is the most common type of melanoma in individuals with dark skin and is notoriously challenging to treat. Our study examined exome sequencing data from 139 tissue samples, spanning different progression stages, collected from 37 patients. We found that 78.4% of the melanomas displayed one or mor...

Topics

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• DNA Copy Number Variations
• Evolution, Molecular
• Exome Sequencing
• MAP Kinase Signaling System
• Melanoma
• Mutation
• Skin Neoplasms
• Telomerase

Identifiers and source

Literature Corpus work

28344e73-d39f-5213-a01a-22db898106d0

DOI

10.1101/2023.10.18.562802