Article
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity.
Nature communications - 16 Oct 2020
Newell Felicity, Wilmott James S, Johansson Peter A, Nones Katia, Addala Venkateswar, Mukhopadhyay Pamela, Broit Natasa, Amato Carol M, Van Gulick Robert, Kazakoff Stephen H, Patch Ann-Marie, Koufariotis Lambros T, Lakis Vanessa, Leonard Conrad, Wood Scott, Holmes Oliver, Xu Qinying, Lewis Karl, Medina Theresa, Gonzalez Rene, Saw Robyn P M, Spillane Andrew J, Stretch Jonathan R, Rawson Robert V, Ferguson Peter M, Dodds Tristan J, Thompson John F, Long Georgina V, Levesque Mitchell P, Robinson William A, Pearson John V, Mann Graham J, Scolyer Richard A, Waddell Nicola, Hayward Nicholas K
Abstract excerpt
To increase understanding of the genomic landscape of acral melanoma, a rare form of melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with matching transcriptome sequencing for 63 tumors was performed. Here we report that mutational signature analysis reveals a subset of tumors, mostly subungual, with an ultraviolet radiation signature. Significantly mutated genes are BRAF,...
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