Article
The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis.
Pigment cell & melanoma research - 1 Sept 2014
Furney Simon J, Turajlic Samra, Stamp Gordon, Thomas J Meirion, Hayes Andrew, Strauss Dirk, Gavrielides Mike, Xing Wei, Gore Martin, Larkin James, Marais Richard
Abstract excerpt
Acral melanoma is a subtype of melanoma with distinct epidemiological, clinical and mutational profiles. To define the genomic alterations in acral melanoma, we conducted whole-genome sequencing and SNP array analysis of five metastatic tumours and their matched normal genomes. We identified the somatic mutations, copy number alterations and structural variants in these tumours and combined our data with...
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